Age-Related Structural Alterations in Human Amygdala Networks: Reflections on Correlations Between White Matter Structure and Effective Connectivity.

ABSTRACT: The amygdala, which is involved in human social information processing and socio-emotional response neuronal circuits, is segmented into three subregions that are responsible for perception, affiliation, and aversion. Though there is different functional and effective connectivity (EC) among these networks, age-related structural changes and associations between structure and function within the amygdala remain unclear. Here, we used diffusion tensor imaging (DTI) data (106 participants) to investigate age-related structural changes in fractional anisotropy (FA) of amygdalar subregions. We also examined the relationship between FA and EC within the subregions. We found that the FA of the amygdalar subregions exhibited inverted-U-shape trends with age. Moreover, over the human lifespan, the

SUBMITTER: Jiang Y 

PROVIDER: S-EPMC6624785 | biostudies-literature | 2019

REPOSITORIES: biostudies-literature