Systolic Blood Pressure and Risk of Valvular Heart Disease: A Mendelian Randomization Study.

ABSTRACT:

Importance

Modifiable risk factors for valvular heart disease remain largely unknown, which limits prevention and treatment.

Objective

To assess the association between systolic blood pressure (BP) and major valvular heart disease.

Design, setting, and participants

A UK Biobank population-based cohort of 502 602 men and women aged 40 to 96 years at baseline was evaluated through mendelian randomization using individual participant data. Inclusion criteria were valid genetic data and BP measurements. The participants were recruited between 2006 and 2010; data analysis was performed from June 2018 to January 2019.

Exposures

Systolic BP was measured during clinical assessment and instruments for the genetic effect of high BP were identified from variants that were

SUBMITTER: Nazarzadeh M 

PROVIDER: S-EPMC6624812 | biostudies-literature | 2019 Aug

REPOSITORIES: biostudies-literature