Value of Molecular Classification for Prognostic Assessment of Adrenocortical Carcinoma.

ABSTRACT:

Importance

The risk stratification of adrenocortical carcinoma (ACC) based on tumor proliferation index and stage is limited. Adjuvant therapy after surgery is recommended for most patients. Pan-genomic studies have identified distinct molecular groups closely associated with outcome.

Objective

To compare the molecular classification for prognostic assessment of ACC with other known prognostic factors.

Design, setting, and participants

In this retrospective biomarker analysis, ACC tumor samples from 368 patients who had undergone surgical tumor removal were collected from March 1, 2005, to September 30, 2015 (144 in the training cohort and 224 in the validation cohort) at 21 referral centers with a median follow-up of 35 months (interquartile range, 18-74 months). Dat

SUBMITTER: Assie G 

PROVIDER: S-EPMC6624825 | biostudies-literature | 2019 Oct

REPOSITORIES: biostudies-literature