Ontology highlight
ABSTRACT:
SUBMITTER: Zamanighomi M
PROVIDER: S-EPMC6624979 | biostudies-literature | 2019 Jul
REPOSITORIES: biostudies-literature
Genome biology 20190712 1
Systems for CRISPR-based combinatorial perturbation of two or more genes are emerging as powerful tools for uncovering genetic interactions. However, systematic identification of these relationships is complicated by sample, reagent, and biological variability. We develop a variational Bayes approach (GEMINI) that jointly analyzes all samples and reagents to identify genetic interactions in pairwise knockout screens. The improved accuracy and scalability of GEMINI enables the systematic analysis ...[more]