Kidney and cystic volume imaging for disease presentation and progression in the cat autosomal dominant polycystic kidney disease large animal model.

ABSTRACT:

Background

Approximately 30% of Persian cats have a c.10063C > A variant in polycystin 1 (PKD1) homolog causing autosomal dominant polycystic kidney disease (ADPKD). The variant is lethal in utero when in the homozygous state and is the only ADPKD variant known in cats. Affected cats have a wide range of progression and disease severity. However, cats are an overlooked biomedical model and have not been used to test therapeutics and diets that may support human clinical trials. To reinvigorate the cat as a large animal model for ADPKD, the efficacy of imaging modalities was evaluated and estimates of kidney and fractional cystic volumes (FCV) determined.

Methods

Three imaging modalities, ultrasonography, computed tomography (CT), and magnetic resonance imaging examined varia

SUBMITTER: Yu Y 

PROVIDER: S-EPMC6625046 | biostudies-literature | 2019 Jul

REPOSITORIES: biostudies-literature