VCF-Server: A web-based visualization tool for high-throughput variant data mining and management.

ABSTRACT:

Background

Next-generation sequencing (NGS) has been widely used in both clinics and research. It has become the most powerful tool for diagnosing genetic disorders and investigating disease etiology through the discovery of genetic variants. Variants identified by NGS are stored in variant call format (VCF) files. However, querying and filtering VCF files are extremely difficult for researchers without programming skills. Furthermore, as the mutation data are increasing exponentially, there is an urgent need to develop tools to manage these variant data in a centralized way.

Methods

The VCF-Server was developed as a web-based visualization tool to support the interactive analysis of genetic variant data. It allows researchers and medical geneticists to manage, annotate, fil

SUBMITTER: Jiang J 

PROVIDER: S-EPMC6625089 | biostudies-literature | 2019 Jul

REPOSITORIES: biostudies-literature