Copy number alterations associated with clinical features in an underrepresented population with breast cancer.

ABSTRACT:

Background

As the most incident tumor among women worldwide, breast cancer is a heterogeneous disease. Tremendous efforts have been made to understand how tumor characteristics as histological type, molecular subtype, and tumor microenvironment collectively influence disease diagnosis to treatment, which impact outcomes. Differences between populations and environmental and cultural factors have impacts on the origin and evolution of the disease, as well as the therapeutic challenges that arise due to these factors. We, then, compared copy number variations (CNVs) in mucinous and nonmucinous luminal breast tumors from a Brazilian cohort to investigate major CNV imbalances in mucinous tumors versus non-mucinous luminal tumors, taking into account their clinical and pathological feat

SUBMITTER: Rodrigues-Peres RM 

PROVIDER: S-EPMC6625096 | biostudies-literature | 2019 Jul

REPOSITORIES: biostudies-literature