Associations between polymorphisms of the ACYP2 gene and Liver cancer risk: A case-control study and meta-analysis.

ABSTRACT:

Background

ACYP2 gene may be involved in the process of telomere shortening which may be involved in the liver cancer. So, this research was to examine whether the ACYP2 gene polymorphism has impact on the risk of liver cancer in Chinese population.

Methods

Two hundred and fifty cirrhosis patients and 248 liver cancer patients were selected. Unconditional logistic regression was to calculate the odds ratio (OR) and 95% confidence intervals (CIs). Analyze the relationship between ACYP2 gene polymorphism and tumor using meta-analysis. Analyze the expression of ACYP2 gene in liver cancer and its influence on the prognosis of liver cancer by databases (Ualcan, GTEX and Kaplan-Meier plotter).

Results

In the allele model, ACYP2 rs843720 was protection against the occurrence

SUBMITTER: Zhao W 

PROVIDER: S-EPMC6625101 | biostudies-literature | 2019 Jul

REPOSITORIES: biostudies-literature