The influence of ACYP2 polymorphisms on gastrointestinal cancer susceptibility in the Chinese Han population.

ABSTRACT:

Background

Gastrointestinal cancer (GI cancer) is a type of cancer that has a high death rate. It has been reported that ACYP2 gene was associated with the development of gastric cancer and colorectal cancer, but it is not clear that the relationship between ACYP2 gene and GI cancer in Chinese Han population. This study aimed to investigate the association between polymorphisms of ACYP2 and GI cancer in the Chinese Han population.

Methods

We used Agena MassARRAY to determine the genotypes of 1,160 GI cancer patients and 495 healthy controls. The correlation between ACYP2 variants and GI cancer risk was examined by logistic regression analysis.

Results

We identified that rs6713088 (OR = 1.17, 95% CI: 1.00-1.36, p = 0.047), rs843711 (OR = 1.17, 95 CI: 1.01-1.36, p = 0.0

SUBMITTER: Duan X 

PROVIDER: S-EPMC6625334 | biostudies-literature | 2019 Jul

REPOSITORIES: biostudies-literature