IL-7R gene polymorphisms among patients with rheumatoid arthritis: A case-control study.

ABSTRACT:

Background

Rheumatoid arthritis (RA) is the most common inflammatory disease which refers to bony erosions and joint destruction largely caused by genetic factors. Our study aimed to explore whether interleukin-7 receptor (IL-7R) gene polymorphisms influenced RA risk in the Han Chinese population.

Methods

Five single nucleotide polymorphisms (SNPs) in IL-7R gene were successfully genotyped using Agena MassARRAY platform. The associations between IL-7R polymorphisms and RA were evaluated by the Chi-squared test, T test, genetic model analysis, and haplotype analysis. We calculated odds ratios (ORs) and 95% confidence intervals (95% CIs) using logistic regression analysis.

Results

Rs969129 and rs6451231 in the IL-7R gene were associated with an increased risk of RA in t

SUBMITTER: Bai M 

PROVIDER: S-EPMC6625337 | biostudies-literature | 2019 Jul

REPOSITORIES: biostudies-literature