Effects of adiposity and metabolic dysfunction on cognition: A review.

ABSTRACT: Obesity and metabolic dysfunction are both correlated with increased rates of cognitive decline. However, because these two conditions often co-occur, it remains unclear whether their cognitive consequences are independent. In this review, we carefully consider literature examining the effects of metabolic dysfunction and increased adiposity on cognition across the lifespan, including only well-controlled studies that attempt to dissociate their effects. We found a total of 36 studies, 17 examining metabolic dysfunction and 19 examining the effects of adiposity. We found evidence from the literature suggesting that increased adiposity and metabolic dysfunction may contribute to deficits in executive function, memory, and medial temporal lobe structures largely independent of one another. T

SUBMITTER: Farruggia MC 

PROVIDER: S-EPMC6625347 | biostudies-literature | 2019 Sep

REPOSITORIES: biostudies-literature