Parotid gland fat related Magnetic Resonance image biomarkers improve prediction of late radiation-induced xerostomia.

ABSTRACT:

Purpose

This study investigated whether Magnetic Resonance image biomarkers (MR-IBMs) were associated with xerostomia 12 months after radiotherapy (Xer_12m) and to test the hypothesis that the ratio of fat-to-functional parotid tissue is related to Xer_12m. Additionally, improvement of the reference Xer_12m model based on parotid gland dose and baseline xerostomia, with MR-IBMs was explored.

Methods

Parotid gland MR-IBMs of 68 head and neck cancer patients were extracted from pre-treatment T1-weighted MR images, which were normalized to fat tissue, quantifying 21 intensity and 43 texture image characteristics. The performance of the resulting multivariable logistic regression models after bootstrapped forward selection was compared with that of

SUBMITTER: van Dijk LV 

PROVIDER: S-EPMC6625348 | biostudies-literature | 2018 Sep

REPOSITORIES: biostudies-literature