Influence of ligand encapsulation on cobalt-59 chemical-shift thermometry.

ABSTRACT: Thermometry via magnetic resonance imaging (MRI) would provide a powerful noninvasive window into physiological temperature management. Cobalt-59 nuclear spins demonstrate exceptional temperature dependence of their NMR chemical shifts, yet the insight to control this dependence via molecular design is lacking. We present the first systematic evidence that encapsulation of this spin system amplifies the temperature sensitivity. We tested the temperature dependence of the ⁵⁹Co chemical shift (Δδ/ΔT) in a series of five low-spin cobalt(iii) complexes as a function of increasing encapsulation within the 1st coordination sphere. This study spans from [Co(NH₃)₆]Cl₃, with no interligand connectivity, to a fully encapsulated

SUBMITTER: Ozvat TM 

PROVIDER: S-EPMC6625495 | biostudies-literature | 2019 Jul

REPOSITORIES: biostudies-literature