The activated newborn neurons participate in enriched environment induced improvement of locomotor function in APP/PS1 mice.

ABSTRACT:

Introduction

Alzheimer's disease (AD) is an age-related neurodegenerative disorder. One of the pathological features of AD is neuronal loss in brain regions associated with cognition, particularly the hippocampus. An enriched environment (EE) can facilitate neuronal plasticity and improve behaviors such as emotion, motor function, and cognition in AD.

Methods

After APP/PS1 mice were exposed to EE at an early stage (2 months of age), elevated plus maze performance and contextual fear conditioning were tested, and neurogenesis and the extent of activation in the hippocampus were observed.

Results

The results showed that, compared with that in the mice that experienced a standard environment, the cognition of the mice exposed to EE, as measured by contextual fear conditi

SUBMITTER: Wang H 

PROVIDER: S-EPMC6625533 | biostudies-literature | 2019 Jul

REPOSITORIES: biostudies-literature