Multimorbidity Patterns, Frailty, and Survival in Community-Dwelling Older Adults.

ABSTRACT:

Background

Frailty and multimorbidity are independent prognostic factors for mortality, but their interaction has not been fully explored. We investigated the importance of multimorbidity patterns in older adults with the same level of frailty phenotype.

Methods

In a cohort of 7,197 community-dwelling adults aged 65 years and older, physical frailty status (robust, pre-frail, frail) was defined using shrinking, exhaustion, inactivity, slowness, and weakness. Latent class analysis was used to identify individuals with multimorbidity patterns based on 10 self-reported chronic conditions. We estimated hazard ratios (HR) and incidence rate differences (IRDs) for mortality comparing multimorbidity patterns within each frailty state.

Results

Five multimorbidity classes were

SUBMITTER: Nguyen QD 

PROVIDER: S-EPMC6625582 | biostudies-literature | 2019 Jul

REPOSITORIES: biostudies-literature