Evaluation of Frailty as an Unmeasured Confounder in Observational Studies of Antidiabetic Medications.

ABSTRACT:

Background

It is unknown whether observational studies evaluating the association between antidiabetic medications and mortality adequately account for frailty. Our objectives were to evaluate if frailty was a potential confounder in the relationship between antidiabetic medication regimen and mortality and how well administrative and clinical electronic health record (EHR) data account for frailty.

Methods

We conducted a retrospective cohort study in a single Veterans Health Administration (VHA) healthcare system of 500 hospitalizations-the majority due to heart failure-of Veterans who received regular VHA care and initiated type 2 diabetes treatment from 2001 to 2008. We measured frailty using a modified frailty index (FI, >0.21 frail). We obtained antidiabetic medication

SUBMITTER: Presley CA 

PROVIDER: S-EPMC6625595 | biostudies-literature | 2019 Jul

REPOSITORIES: biostudies-literature