Preformed Donor-Specific HLA Antibodies in Living and Deceased Donor Transplantation: A Multicenter Study.

ABSTRACT:

Background and objectives

The prognostic value of preformed donor-specific HLA antibodies (DSA), which are only detectable by sensitive methods, remains controversial for kidney transplantation.

Design, setting, participants, & measurements

The outcome of 4233 consecutive kidney transplants performed between 2012 and 2015 in 18 German transplant centers was evaluated. Most centers used a stepwise pretransplant antibody screening with bead array tests and differentiation of positive samples by single antigen assays. Using these screening results, DSA against HLA-A, -B, -C, -DRB1 and -DQB1 were determined. Data on clinical outcome and possible covariates were collected retrospectively.

Results

Pretransplant DSA were associated with lower overall graft survival, with a h

SUBMITTER: Ziemann M 

PROVIDER: S-EPMC6625630 | biostudies-literature | 2019 Jul

REPOSITORIES: biostudies-literature