Effects of Treatment of Metabolic Acidosis in CKD: A Systematic Review and Meta-Analysis.

ABSTRACT:

Background and objectives

Metabolic acidosis is associated with progression of CKD and has significant adverse effects on muscle and bone. A systematic review and meta-analysis was conducted to evaluate the benefits and risks of metabolic acidosis treatment with oral alkali supplementation or a reduction of dietary acid intake in those with CKD.

Design, setting, participants, & measurements

MEDLINE, Embase, and Cochrane CENTRAL were searched for relevant trials in patients with stage 3-5 CKD and metabolic acidosis (<22 mEq/L) or low-normal serum bicarbonate (22-24 mEq/L). Data were pooled in a meta-analysis with results expressed as weighted mean difference for continuous outcomes and relative risk for categorical outcomes with 95% confidence intervals (95% CIs), using a ran

SUBMITTER: Navaneethan SD 

PROVIDER: S-EPMC6625635 | biostudies-literature | 2019 Jul

REPOSITORIES: biostudies-literature