A polymorphic helix of a Salmonella needle protein relays signals defining distinct steps in type III secretion.

ABSTRACT: Type III protein-secretion machines are essential for the interactions of many pathogenic or symbiotic bacterial species with their respective eukaryotic hosts. The core component of these machines is the injectisome, a multiprotein complex that mediates the selection of substrates, their passage through the bacterial envelope, and ultimately their delivery into eukaryotic target cells. The injectisome is composed of a large cytoplasmic complex or sorting platform, a multiring base embedded in the bacterial envelope, and a needle-like filament that protrudes several nanometers from the bacterial surface and is capped at its distal end by the tip complex. A characteristic feature of these machines is that their activity is stimulated by contact with target host cells. The sensing of target

SUBMITTER: Guo EZ 

PROVIDER: S-EPMC6625726 | biostudies-literature | 2019 Jul

REPOSITORIES: biostudies-literature