A secretion-enhancing cis regulatory targeting element (SECReTE) involved in mRNA localization and protein synthesis.

ABSTRACT: The localization of mRNAs encoding secreted/membrane proteins (mSMPs) to the endoplasmic reticulum (ER) likely facilitates the co-translational translocation of secreted proteins. However, studies have shown that mSMP recruitment to the ER in eukaryotes can occur in a manner that is independent of the ribosome, translational control, and the signal recognition particle, although the mechanism remains largely unknown. Here, we identify a cis-acting RNA sequence motif that enhances mSMP localization to the ER and appears to increase mRNA stability, and both the synthesis and secretion of secretome proteins. Termed SECReTE, for secretion-enhancing cis regulatory targeting element, this motif is enriched in mRNAs encoding secretome proteins translated on the ER in eukaryotes and on the inner m

SUBMITTER: Cohen-Zontag O 

PROVIDER: S-EPMC6625729 | biostudies-literature | 2019 Jul

REPOSITORIES: biostudies-literature