Salmonella Membrane Structural Remodeling Increases Resistance to Antimicrobial Peptide LL-37.

ABSTRACT: Gram-negative bacteria are protected from their environment by an outer membrane that is primarily composed of lipopolysaccharides (LPSs). Under stress, pathogenic serotypes of Salmonella enterica remodel their LPSs through the PhoPQ two-component regulatory system that increases resistance to both conventional antibiotics and antimicrobial peptides (AMPs). Acquired resistance to AMPs is contrary to the established narrative that AMPs circumvent bacterial resistance by targeting the general chemical properties of membrane lipids. However, the specific mechanisms underlying AMP resistance remain elusive. Here we report a 2-fold increase in bacteriostatic concentrations of human AMP LL-37 for S. enterica with modified LPSs. LPSs with and without chemical modifications were isol

SUBMITTER: Martynowycz MW 

PROVIDER: S-EPMC6625857 | biostudies-literature | 2019 Jul

REPOSITORIES: biostudies-literature