Immunological and Neurometabolite Changes Associated With Switch From Efavirenz to an Integrase Inhibitor.

ABSTRACT:

Background

The biological mechanisms by which efavirenz (EFV) causes central nervous system (CNS) effects are unclear. The objective of this pilot study was to elucidate the mechanisms underlying these CNS effects by correlating well-described neuropsychological (NP) changes with neurometabolites and immunologic markers following switch off EFV.

Setting

Two single-arm parallel switch studies among HIV-infected adults in Boston, USA, from 2015 to 2017.

Methods

Twenty asymptomatic HIV-infected adults on EFV-containing regimens were switched to an integrase strand transfer inhibitor-based regimen for 8 weeks. NP assessments were conducted before and after switch and correlated with neurometabolite changes measured using magnetic resonance spectroscopy and immunological m

SUBMITTER: Asundi A 

PROVIDER: S-EPMC6625862 | biostudies-literature | 2019 Aug

REPOSITORIES: biostudies-literature