Corticolimbic fast-tracking: enhanced multimodal integration in functional neurological disorder.

ABSTRACT:

Objective

Some individuals with functional neurological disorder (FND) exhibit motor and affective disturbances, along with limbic hyper-reactivity and enhanced motor-limbic connectivity. Given that the multimodal integration network (insula, dorsal cingulate, temporoparietal junction (TPJ)) is implicated in convergent sensorimotor, affective and interoceptive processing, we hypothesised that patients with FND would exhibit altered motor and amygdalar resting-state propagation to this network. Patient-reported symptom severity and clinical outcome were also hypothesised to map onto multimodal integration areas.

Methods

Between-group differences in primary motor and amygdalar nuclei (laterobasal, centromedial) were examined using graph-theory stepwise functional connectivity

SUBMITTER: Diez I 

PROVIDER: S-EPMC6625895 | biostudies-literature | 2019 Aug

REPOSITORIES: biostudies-literature