Cancer-attributable mortality among solid organ transplant recipients in the United States: 1987 through 2014.

ABSTRACT:

Background

Solid organ transplant recipients have an elevated risk of cancer. Quantifying deaths attributable to cancer can inform priorities to reduce cancer burden.

Methods

Linked transplantation and cancer registry data were used to identify incident cancers and deaths among solid organ transplant recipients in the United States (1987-2014). Population-attributable fractions (PAFs) of deaths due to cancer and corresponding cancer-attributable mortality rates were estimated using Cox models.

Results

Among 221,962 solid organ transplant recipients, 15,012 developed cancer. Approximately 13% of deaths (PAF, 13.2%) were attributable to cancer, corresponding to a cancer-attributable mortality rate of 516 per 100,000 person-years. Lung cancer was the largest contributor

SUBMITTER: Noone AM 

PROVIDER: S-EPMC6625902 | biostudies-literature | 2019 Aug

REPOSITORIES: biostudies-literature