Objective assessment of the effects of tumor motion in radiation therapy.

ABSTRACT:

Purpose

Internal organ motion reduces the accuracy and efficacy of radiation therapy. However, there is a lack of tools to objectively (based on a medical or scientific task) assess the dosimetric consequences of motion, especially on an individual basis. We propose to use therapy operating characteristic (TOC) analysis to quantify the effects of motion on treatment efficacy for individual patients. We demonstrate the application of this tool with pancreatic stereotactic body radiation therapy (SBRT) clinical data and explore the origin of motion sensitivity.

Methods

The technique is described as follows. (a) Use tumor-motion data measured from patients to calculate the motion-convolved dose of the gross tumor volume (GTV) and the organs at risk (OARs). (b) Calculate tumor c

SUBMITTER: Ding Y 

PROVIDER: S-EPMC6625917 | biostudies-literature | 2019 Jul

REPOSITORIES: biostudies-literature