Anti-androgenic therapy with finasteride in patients with chronic heart failure - a retrospective propensity score based analysis.

ABSTRACT: Sex hormones influence the prevalence and the outcome of heart diseases. The conversion of testosterone to its more active metabolite dihydrotestosterone drives cardiac growth and dysfunction, while inhibition of this step by the anti-androgenic drug finasteride counteracts these pathological processes in preclinical models. In this retrospective, observational study, we aim to investigate whether finasteride, which is in clinical use mainly for prostate disease, might ameliorate cardiac hypertrophy and heart failure in patients. Retrospective chart review of 1041 medical cases with heart failure between 1995 and 2015 was conducted. Stratification was performed by concomitant prostate treatment status (tamsulosin versus finasteride). A propensity score analysis yielded a total of 328 match

SUBMITTER: Kattih B 

PROVIDER: S-EPMC6626053 | biostudies-literature | 2019 Jul

REPOSITORIES: biostudies-literature