Activation of vitamin D in the gingival epithelium and its role in gingival inflammation and alveolar bone loss.

ABSTRACT:

Background and objective

Both chronic and aggressive periodontal disease are associated with vitamin D deficiency. The active form of vitamin D, 1,25(OH)₂ D₃ , induces the expression of the antimicrobial peptide LL-37 and innate immune mediators in cultured human gingival epithelial cells (GECs). The aim of this study was to further delineate the mechanism by which vitamin D enhances the innate defense against the development of periodontal disease (PD).

Materials and methods

Wild-type C57Bl/6 mice were made deficient in vitamin D by dietary restriction. Cultured primary and immortalized GEC were stimulated with 1,25(OH)₂ D₃ , followed by infection with Porphyromonas gingivalis, and viable intracellular bacteria were quantified. Co

SUBMITTER: Menzel LP 

PROVIDER: S-EPMC6626553 | biostudies-literature | 2019 Aug

REPOSITORIES: biostudies-literature