The cytoplasmic portion of the T3SS inner membrane ring components sort into distinct families based on biophysical properties.

ABSTRACT: Type III secretion systems are used by many Gram-negative bacteria to inject effector proteins into eukaryotic cells to subvert their normal activities. Structurally conserved portions of the type III secretion apparatus include a: basal body located within the bacterial envelope; an exposed needle with tip complex that delivers effectors across the target cell membrane; and cytoplasmic sorting platform that selects cargo and powers secretion. While structurally conserved, the individual proteins that make up this nanomachine are typically not interchangeable though they do tend to fall into families. Here we selected a single domain from the inner membrane ring of the basal body from six different type III secretion systems (called SctD using a proposed unifying nomenclature). The selecte

SUBMITTER: Muthuramalingam M 

PROVIDER: S-EPMC6626570 | biostudies-literature | 2019 Sep

REPOSITORIES: biostudies-literature