Unbiased transcriptomic analyses reveal distinct effects of immune deficiency in CNS function with and without injury.

ABSTRACT: The mammalian central nervous system (CNS) is considered an immune privileged system as it is separated from the periphery by the blood brain barrier (BBB). Yet, immune functions have been postulated to heavily influence the functional state of the CNS, especially after injury or during neurodegeneration. There is controversy regarding whether adaptive immune responses are beneficial or detrimental to CNS injury repair. In this study, we utilized immunocompromised SCID mice and subjected them to spinal cord injury (SCI). We analyzed motor function, electrophysiology, histochemistry, and performed unbiased RNA-sequencing. SCID mice displayed improved CNS functional recovery compared to WT mice after SCI. Weighted gene-coexpression network analysis (WGCNA) of spinal cord transcriptomes revea

SUBMITTER: Luo D 

PROVIDER: S-EPMC6626597 | biostudies-literature | 2019 Aug

REPOSITORIES: biostudies-literature