Independent and joint association of obesity and metabolic syndrome with depression and inflammation.

ABSTRACT:

Objective

To investigate the separate and combined associations of obesity and metabolic syndrome (MetS) with depression and the role of inflammation.

Method

Depression was assessed with the Patient Health Questionnaire-9 (PHQ-9) and was defined with a cutpoint of ≥10. Obesity was defined as body mass index (BMI) ≥30 kg/m2 from measured height and weight. MetS was defined based on the American Heart Association consensus definition. Participants were divided into four groups: healthy normal weight (MHN), metabolically healthy obese (MHO), metabolically unhealthy normal weight (MUN), and metabolic unhealthy obese (MUO). C-Reactive protein was assessed in a subsample.

Results

A total of 18,025 subjects were included in the analysis. Participants with MUO had the highest

SUBMITTER: Moazzami K 

PROVIDER: S-EPMC6626601 | biostudies-literature | 2019 Jul

REPOSITORIES: biostudies-literature