Human and computational models of atopic dermatitis: A review and perspectives by an expert panel of the International Eczema Council.

ABSTRACT: Atopic dermatitis (AD) is a prevalent disease worldwide and is associated with systemic comorbidities representing a significant burden on patients, their families, and society. Therapeutic options for AD remain limited, in part because of a lack of well-characterized animal models. There has been increasing interest in developing experimental approaches to study the pathogenesis of human AD in vivo, in vitro, and in silico to better define pathophysiologic mechanisms and identify novel therapeutic targets and biomarkers that predict therapeutic response. This review critically appraises a range of models, including genetic mutations relevant to AD, experimental challenge of human skin in vivo, tissue culture models, integration of "omics" data sets, and development of predictive computati

SUBMITTER: Eyerich K 

PROVIDER: S-EPMC6626639 | biostudies-literature | 2019 Jan

REPOSITORIES: biostudies-literature