Effects of intrastriatal dopamine D1 or D2 antagonists on methamphetamine-induced egocentric and allocentric learning and memory deficits in Sprague-Dawley rats.

ABSTRACT: RATIONALE:Methamphetamine (MA) is an abused psychostimulant that causes cognitive deficits after chronic use. Neostriatal dopamine receptors play a role in MA monoamine neurotoxicity. Blocking dopamine receptors prior to MA exposure in adult rats attenuates monoamine reductions and reactive gliosis. OBJECTIVES:We tested whether blocking dopamine receptors protects against cognitive deficits. METHODS:First, we determined the effects of MA alone versus MA in combination with the dopamine receptor D1 antagonist SCH-23390 or the dopamine receptor D2 antagonist sulpiride on cFos expression and monoamines at the age when rats in the cognitive experiment were to begin testing and monoamines in rats after cognitive testing. RESULTS:SCH-23390 infused into the neostriatum prior to systemic administr

SUBMITTER: Gutierrez A 

PROVIDER: S-EPMC6626678 | biostudies-literature | 2019 Jul

REPOSITORIES: biostudies-literature