Renal Adiposity Does not Preclude Quantitative Assessment of Renal Function Using Dual-Energy Multidetector CT in Mildly Obese Human Subjects.

ABSTRACT:

Rationale and objectives

Multidetector computed tomography (MDCT) is useful for measuring in the research setting single-kidney perfusion and function using iodinated contrast time-attenuation curves. Obesity promotes deposition of intrarenal fat, which might decrease tissue attenuation and thereby interfere with quantification of renal function using MDCT. The purpose of this study was to test the hypothesis that background subtraction adequately accounts for intrarenal fat deposition in mildly obese human subjects during renal contrast enhanced dynamic CT.

Materials and methods

We prospectively recruited seventeen human subjects stratified as lean or mildly obese based on body mass index below or over 30 kg/m², respectively. Renal perfusion was quantified from C

SUBMITTER: Ferguson CM 

PROVIDER: S-EPMC6626692 | biostudies-literature | 2019 Nov

REPOSITORIES: biostudies-literature