Impact of patient background factors on the treatment efficacy of once-weekly teriparatide.

ABSTRACT:

Objectives

The impact of patient background factors on changes in bone mineral density (BMD) and bone metabolic markers after treatment with once-weekly teriparatide (W-TPTD) has not been fully elucidated. To clarify the impact, I performed stratified analysis in addition to the efficacy and safety assessments to analyze treatment data with W-TPTD.

Methods

The primary endpoint of the efficacy was the rate of change of the lumbar spine BMD at 18 months after treatment. In the exploratory analysis, bone metabolic markers at baseline were used to divide the patients into 3 groups, by the first tertile and the second tertile. The rate of change in the lumbar spine/femoral neck BMD and bone metabolic markers in each group were analyzed by stratification.

Results

The rate o

SUBMITTER: Omura F 

PROVIDER: S-EPMC6626838 | biostudies-literature | 2019 Jun

REPOSITORIES: biostudies-literature