Mechanochemical Coupling and Junctional Forces during Collective Cell Migration.

ABSTRACT: Cell migration, a fundamental physiological process in which cells sense and move through their surrounding physical environment, plays a critical role in development and tissue formation, as well as pathological processes, such as cancer metastasis and wound healing. During cell migration, dynamics are governed by the bidirectional interplay between cell-generated mechanical forces and the activity of Rho GTPases, a family of small GTP-binding proteins that regulate actin cytoskeleton assembly and cellular contractility. These interactions are inherently more complex during the collective migration of mechanically coupled cells because of the additional regulation of cell-cell junctional forces. In this study, we adapted a recent minimal modeling framework to simulate the interactions bet

SUBMITTER: Bui J 

PROVIDER: S-EPMC6626874 | biostudies-literature | 2019 Jul

REPOSITORIES: biostudies-literature