Computer Modeling of Clonal Dominance: Memory-Anti-Naive and Its Curbing by Attrition.

ABSTRACT: Experimental and computational studies have revealed that T-cell cross-reactivity is a widespread phenomenon that can either be advantageous or detrimental to the host. In particular, detrimental effects can occur whenever the clonal dominance of memory cells is not justified by their infection-clearing capacity. Using an agent-based model of the immune system, we recently predicted the "memory anti-naïve" phenomenon, which occurs when the secondary challenge is similar but not identical to the primary stimulation. In this case, the pre-existing memory cells formed during the primary infection may be rapidly deployed in spite of their low affinity and can actually prevent a potentially higher affinity naïve response from emerging, resulting in impaired viral clearance. This finding allowed

SUBMITTER: Castiglione F 

PROVIDER: S-EPMC6626922 | biostudies-literature | 2019

REPOSITORIES: biostudies-literature