Glucose-dependent insulinotropic polypeptide deficiency reduced fat accumulation and insulin resistance, but deteriorated bone loss in ovariectomized mice.

ABSTRACT: Given the established roles of glucose-dependent insulinotropic polypeptide (GIP) in promoting fat storage and bone formation, we assessed the contribution of GIP to obesity and osteopenia in ovariectomized mice with a gene encoding green fluorescent protein (GFP) inserted into the GIP locus, in which GIP was either reduced (GIP^gfp/+ ) or absent (GIP^gfp/gfp ). In GIP^gfp/gfp mice, weight gain, subcutaneous and visceral fat mass were reduced, and glucose intolerance was improved compared with wild-type mice with the same magnitude of insulin responses. Cancellous bone mineral density and bone cortical thickness were reduced in GIP^gfp/gfp mice compared with wild-type mice. In GIP^gfp/+ mice, weight gain, glucose intolerance and cancellous

SUBMITTER: Shimazu-Kuwahara S 

PROVIDER: S-EPMC6626948 | biostudies-literature | 2019 Jul

REPOSITORIES: biostudies-literature