Genetic variants in DNMT1 and the risk of cardiac autonomic neuropathy in women with type 1 diabetes.

ABSTRACT:

Aims/introduction

Epigenetics participate in the pathogenesis of metabolic memory, a situation in which hyperglycemia exerts prolonged deleterious effects even after its normalization. We tested the hypothesis that genetic variants in an epigenetic gene could predispose to diabetes complications.

Material and methods

We assessed the frequency of five single-nucleotide polymorphisms in the gene encoding deoxyribonucleic acid methytransferase 1 (DNMT1; rs8112895, rs7254567, rs11085721, rs17291414 and rs10854076), and their associations with diabetic kidney disease, retinopathy, distal polyneuropathy and autonomic cardiovascular neuropathy in 359 individuals with long-term type 1 diabetes.

Results

None of the single-nucleotide polymorphisms studied was significantly asso

SUBMITTER: Santos-Bezerra DP 

PROVIDER: S-EPMC6626951 | biostudies-literature | 2019 Jul

REPOSITORIES: biostudies-literature