Independent links between plasma xanthine oxidoreductase activity and levels of adipokines.

ABSTRACT:

Aims/introduction

Xanthine oxidoreductase (XOR) is a rate-limiting enzyme that catalyzes uric acid formation in the purine metabolism, is involved in an increase in reactive oxygen species. Plasma XOR activity has been shown to be associated with obesity, smoking, liver dysfunction, hyperuricemia, dyslipidemia and insulin resistance.

Materials and methods

The association between plasma XOR activity, measured by using liquid chromatography and mass spectrometry, and levels of adipokines, including adiponectin, fatty acid-binding protein 4 (FABP4) and fibroblast growth factor 21 (FGF21), was investigated in 282 participants (male/female: 126/156) of the Tanno-Sobetsu Study who were not taking medication.

Results

Women had lower plasma XOR activity than did men. Smoking

SUBMITTER: Furuhashi M 

PROVIDER: S-EPMC6626953 | biostudies-literature | 2019 Jul

REPOSITORIES: biostudies-literature