Helicobacter pylori eradication improves glycemic control in type 2 diabetes patients with asymptomatic active Helicobacter pylori infection.

ABSTRACT:

Aims/introduction

Helicobacter pylori infection is associated with insulin resistance and glycemia in non-diabetes. However, the relationship between H. pylori infection and glycemia in diabetes remains inconclusive. Therefore, we explored the effect of H. pylori infection status and its eradication on glycemic control and antidiabetic therapy in type 2 diabetes patients.

Materials and methods

A total of 549 diabetes patients were recruited for sequential two-step approach (immunoglobulin G [IgG] serology followed by ¹³ C-urea breath test [UBT]) to discriminate "active" (IgG+ and UBT+) from "non-active" (UBT- or IgG-) H. pylori infection, and "past" (IgG+ but UBT-) from "never/remote" (IgG-) infection. The differences in hemoglobin A1c (A1C) and antidiabetic regim

SUBMITTER: Cheng KP 

PROVIDER: S-EPMC6626959 | biostudies-literature | 2019 Jul

REPOSITORIES: biostudies-literature