IL7RA rs6897932 Polymorphism is Associated with Better CD4⁺ T-Cell Recovery in HIV Infected Patients Starting Combination Antiretroviral Therapy.

ABSTRACT: Interleukin-7 receptor subunit alpha (IL7RA) rs6897932 polymorphism is related to CD4⁺ recovery after combination antiretroviral therapy (cART), but no studies so far have analyzed its potential impact in patients with very low CD4⁺ T-cells count. We aimed to analyze the association between IL7RA rs6897932 polymorphism and CD4⁺ T-cells count restoration in HIV-infected patients starting combination antiretroviral therapy (cART) with CD4⁺ T-cells count <200 cells/mm³. We performed a retrospective study in 411 patients followed for 24 months with a DNA sample available for genotyping. The change in CD4⁺ T-cells count during the follow-up was considered as the primary outcome. The rs6897932 polymorphism had a minimum all

SUBMITTER: Resino S 

PROVIDER: S-EPMC6627042 | biostudies-literature | 2019 Jun

REPOSITORIES: biostudies-literature