Nervous-Like Circuits in the Ribosome Facts, Hypotheses and Perspectives.

ABSTRACT: In the past few decades, studies on translation have converged towards the metaphor of a "ribosome nanomachine"; they also revealed intriguing ribosome properties challenging this view. Many studies have shown that to perform an accurate protein synthesis in a fluctuating cellular environment, ribosomes sense, transfer information and even make decisions. This complex "behaviour" that goes far beyond the skills of a simple mechanical machine has suggested that the ribosomal protein networks could play a role equivalent to nervous circuits at a molecular scale to enable information transfer and processing during translation. We analyse here the significance of this analogy and establish a preliminary link between two fields: ribosome structure-function studies and the analysis of informatio

SUBMITTER: Timsit Y 

PROVIDER: S-EPMC6627100 | biostudies-literature | 2019 Jun

REPOSITORIES: biostudies-literature