The Potential of Carnosine in Brain-Related Disorders: A Comprehensive Review of Current Evidence.

ABSTRACT: Neurological, neurodegenerative, and psychiatric disorders represent a serious burden because of their increasing prevalence, risk of disability, and the lack of effective causal/disease-modifying treatments. There is a growing body of evidence indicating potentially favourable effects of carnosine, which is an over-the-counter food supplement, in peripheral tissues. Although most studies to date have focused on the role of carnosine in metabolic and cardiovascular disorders, the physiological presence of this di-peptide and its analogues in the brain together with their ability to cross the blood-brain barrier as well as evidence from in vitro, animal, and human studies suggest carnosine as a promising therapeutic target in brain disorders. In this review, we aim to provide a comprehensiv

SUBMITTER: Schon M 

PROVIDER: S-EPMC6627134 | biostudies-literature | 2019 May

REPOSITORIES: biostudies-literature