Ontology highlight
ABSTRACT:
SUBMITTER: Quarantotti V
PROVIDER: S-EPMC6627235 | biostudies-literature | 2019 Jul
REPOSITORIES: biostudies-literature
Quarantotti Valentina V Chen Jia-Xuan JX Tischer Julia J Gonzalez Tejedo Carmen C Papachristou Evaggelia K EK D'Santos Clive S CS Kilmartin John V JV Miller Martin L ML Gergely Fanni F
The EMBO journal 20190603 14
Centrioles are core structural elements of both centrosomes and cilia. Although cytoplasmic granules called centriolar satellites have been observed around these structures, lack of a comprehensive inventory of satellite proteins impedes our understanding of their ancestry. To address this, we performed mass spectrometry (MS)-based proteome profiling of centriolar satellites obtained by affinity purification of their key constituent, PCM1, from sucrose gradient fractions. We defined an interacto ...[more]