Methylome-Wide Association Study in Peripheral White Blood Cells Focusing on Central Obesity and Inflammation.

ABSTRACT: Epigenetic signatures such as DNA methylation may be associated with specific obesity traits in different tissues. The onset and development of some obesity-related complications are often linked to visceral fat accumulation. The aim of this study was to explore DNA methylation levels in peripheral white blood cells to identify epigenetic methylation marks associated with waist circumference (WC). DNA methylation levels were assessed using Infinium Human Methylation 450K and MethylationEPIC beadchip (Illumina) to search for putative associations with WC values of 473 participants from the Methyl Epigenome Network Association (MENA) project. Statistical analysis and Ingenuity Pathway Analysis (IPA) were employed for assessing the relationship between methylation and WC. A total of 669 CpGs

SUBMITTER: Arpon A 

PROVIDER: S-EPMC6627499 | biostudies-literature | 2019 Jun

REPOSITORIES: biostudies-literature