KIF3B protein expression loss correlates with metastatic ability of prostate cancer.

ABSTRACT: Kinesin family member 3B (KIF3B) is a microtubule motor kinesin involved in mitotic progression and vasculotropism. A novel therapeutic target, it is overexpressed in several cancers [PMID 29904055]. Its significance in prostate cancer (PC) was uncertain.

Methods

89 cases, including tissue microarrays from 70 prostatectomies comprising matched cancer and benign spots, 19 additional prostatectomy tissues, plus 16 prostate cancer metastases (7 nodal and 9 distant sites; 8 had matched primary PC) were stained with rabbit polyclonal KIF3B antibody. Cytoplasmic immunoreactivity was scored: 0 (negative) to 3+ (strong and diffuse). 39 patients had no nodal metastases, 31 had positive lymph nodes, and 19 had nodes not sampled. Gleason grade groups were 1 (9), 2 (28), 3 (39), 4 (1), and 5 (1

SUBMITTER: Kravtsov O 

PROVIDER: S-EPMC6627541 | biostudies-literature | 2019

REPOSITORIES: biostudies-literature