Purinergic Calcium Signals in Tumor-Derived Endothelium.

ABSTRACT: Tumor microenvironment is particularly enriched with extracellular ATP (eATP), but conflicting evidence has been provided on its functional effects on tumor growth and vascular remodeling. We have previously shown that high eATP concentrations exert a strong anti-migratory, antiangiogenic and normalizing activity on human tumor-derived endothelial cells (TECs). Since both metabotropic and ionotropic purinergic receptors trigger cytosolic calcium increase ([Ca²⁺]c), the present work investigated the properties of [Ca²⁺]c events elicited by high eATP in TECs and their role in anti-migratory activity. In particular, the quantitative and kinetic properties of purinergic-induced Ca²⁺ release from intracellular stores and Ca²⁺ entry from extracellular

SUBMITTER: Scarpellino G 

PROVIDER: S-EPMC6627696 | biostudies-literature | 2019 Jun

REPOSITORIES: biostudies-literature