In Vitro and In Vivo Neuroprotective Effects of Stellettin B Through Anti-Apoptosis and the Nrf2/HO-1 Pathway.
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ABSTRACT:
SUBMITTER: Feng CW
PROVIDER: S-EPMC6627894 | biostudies-literature | 2019 May
REPOSITORIES: biostudies-literature
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In Vitro and In Vivo Neuroprotective Effects of Stellettin B Through Anti-Apoptosis and the Nrf2/HO-1 Pathway.
Feng Chien-Wei CW Chen Nan-Fu NF Wen Zhi-Hong ZH Yang Wen-Ya WY Kuo Hsiao-Mei HM Sung Ping-Jyun PJ Su Jui-Hsin JH Cheng Shu-Yu SY Chen Wu-Fu WF
Marine drugs 20190529 6
Pharmaceutical agents for halting the progression of Parkinson's disease (PD) are lacking. The current available medications only relieve clinical symptoms and may cause severe side effects. Therefore, there is an urgent need for novel drug candidates for PD. In this study, we demonstrated the neuroprotective activity of stellettin B (SB), a compound isolated from marine sponges. We showed that SB could significantly protect SH-SY5Y cells against 6-OHDA-induced cellular damage by inhibiting cell ...[more]
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