Chromogranin-A Expression as a Novel Biomarker for Early Diagnosis of Colon Cancer Patients.

ABSTRACT: Colon cancer is one of the major causes of cancer death worldwide. The five-year survival rate for the early-stage patients is more than 90%, and only around 10% for the later stages. Moreover, half of the colon cancer patients have been clinically diagnosed at the later stages. It is; therefore, of importance to enhance the ability for the early diagnosis of colon cancer. Taking advantages from our previous studies, there are several potential biomarkers which have been associated with the early diagnosis of the colon cancer. In order to investigate these early diagnostic biomarkers for colon cancer, human chromogranin-A (CHGA) was further analyzed among the most powerful diagnostic biomarkers. In this study, we used a logistic regression-based meta-analysis to clarify associations of CHG

SUBMITTER: Zhang X 

PROVIDER: S-EPMC6628020 | biostudies-literature | 2019 Jun

REPOSITORIES: biostudies-literature