Synthesis and Enhanced Cellular Uptake In Vitro of Anti-HER2 Multifunctional Gold Nanoparticles.

ABSTRACT: Nanoparticle carriers offer the possibility of enhanced delivery of therapeutic payloads in tumor tissues due to tumor-selective accumulation through the enhanced permeability and retention effect (EPR). Gold nanoparticles (AuNP), in particular, possess highly appealing features for development as nanomedicines, such as biocompatibility, tunable optical properties and a remarkable ease of surface functionalization. Taking advantage of the latter, several strategies have been designed to increase treatment specificity of gold nanocarriers by attaching monoclonal antibodies on the surface, as a way to promote selective interactions with the targeted cells-an approach referred to as active-targeting. Here, we describe the synthesis of spherical gold nanoparticles surface-functionalized with a

SUBMITTER: Cruz E 

PROVIDER: S-EPMC6628063 | biostudies-literature | 2019 Jun

REPOSITORIES: biostudies-literature